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The most visible effect is gradual skin pigmentation due to MC1R activation in melanocytes
Its role in synthesizing and exporting very-low-density lipoproteins (VLDL) from the liver makes it a key molecule of interest in studies of hepatic lipid homeostasis
The crucial cellular event is enhanced tyrosinase activity
Subsequent cellular experiments confirmed that PLIN2 enhanced IMF deposition by promoting the proliferation and differentiation of intramuscular preadipocytes while inhibiting apoptosis [59]
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10.1038/s41386-018-0136-3 181
Adequate levels protect cells, support immunity and maintain liver and brain health
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