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Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits

This translates to dropping 4-5 clothing sizes and significant improvements in energy levels, joint comfort, and overall mobility

Most patients experience improvement in symptoms after 48 weeks of continued treatment as physiological adaptation occurs

For brands looking to stay ahead of this volatility, these four takeaways offer a roadmap to navigating the GLP-1 era

Presence of cytogenetic abnormalities in Spitz naevi: a diagnostic challenge for fluorescence in-situ hybridization analysis

The standard once-weekly dosing schedule is what was tested in clinical trials and proven effective for weight loss