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Another small, randomized, double-blind trial in 93 individuals with low vitamin D status found no additional benefit of B-vitamin supplementation (50 mg/day of vitamin B6, 0.5 mg/day of folic acid, and 0.5 mg/day of vitamin B 12 ) on markers of bone health over a one-year period beyond that associated with vitamin D and calcium supplementation

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Cyanocobalamin is generally considered safe in pregnancy

If you are not deficient, the energy boost is minimal

Reitman recommends baseline blood work to confirm deficiency and rule out other causes of fatigue