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Since cellular senescence is considered a natural defense mechanism against tumor development, and senescence inductions triggered by currently applied therapies can significantly impact their effectiveness, it is assumed that purposeful stimulation of senescence in cancer cells may be a promising direction in the development of anticancer therapy [8, 15, 55]

The mechanism determines the side effects you will experience, how long you can safely take the medication, what monitoring your doctor needs to do, and ultimately how much weight you can expect to lose

Spector, D., Labarre, J

Semin Arthr Rheum

Patients with certain variants may experience more initial nausea but often benefit from microdose approaches or specific formulations

Schoustra et al., 2019