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Although breast cancer cell lines exhibit increased resilience to physiologically relevant shear stress compared to normal epithelial cells [223], lamin A/C knockdown exacerbates shear stress-mediated tumor cell death [223], suggesting that elevated lamin A/C levels could aid breast CTCs in withstanding shear forces in the circulation

Mar 20 2021;10(3)doi:10.3390/biology10030241

The most common method is to have a blood test done

However, it was withdrawn in the 1960s due to reported renal and hepatic toxicities

If you have confirmed a true plateau, the next step depends on where you are in the escalation schedule