Whereas disassembly is the primary mechanism responsible for the resolution of SGs formed in response to relatively short periods of exposure to stressors (e.g., 30- to 60-min HS or SA treatment) as were used in this study, autophagy has been implicated in the clearance of persistent SGs formed in response to more prolonged stresses (e.g., 90- to 120-min HS treatment) ( 3 , 4 , 27 )
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NAD+ therapy has also been found to improve kidney function in animal models of kidney disease