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Chronically high glucose fuels a flood of free radicals, and over time patients are left with less of the reduced, protective form of GSH and more of the oxidized, exhausted kind a red flag of cellular stress
In tumor cells, GSH metabolism pathways are often remodeled to cope with oxidative stress and metabolic demands brought about by rapid proliferation (15)
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Infants with PWS also show other clinical signs of GHD, such as low muscle tone, small hands and feet, increased body fat percentage, and reduced lean mass
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