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GHRP-6s receptor was originally called the growth hormone secretagogue receptor (GHSR), but due to subsequent discoveries, the hormone ghrelin is now considered the receptors natural endogenous ligand and the receptor has been renamed the ghrelin receptor

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A 2025 study published in JAMA Network Open found that most patients with obesity discontinue GLP-1 therapy within a year, particularly those without type 2 diabetes 1