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Alterations of these metabolites contribute to the regulation of hypoxic response, red blood cell sickling, inflammation, and clinical disease severity 11

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Patients on prolonged INH therapy often receive supplemental pyridoxine to prevent peripheral neuropathy, an adverse effect related to B deficiency

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PI3 kinase/Akt/HIF-1 pathway is associated with hypoxia-induced epithelialmesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis