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Clinical studies reveal semaglutide's potential for a 15-20% body weight reduction when coupled with lifestyle adjustments

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The trial measures major adverse cardiovascular events (MACE), including heart attack, stroke, and cardiovascular death

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According to the American Diabetes Association Standards of Care, GLP-1 receptor agonists produce weight loss through multiple mechanisms including central appetite regulation and delayed gastric emptying, beyond gastrointestinal side effects alone

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