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Crucially, electrophysiological recordings revealed that T4 overexpression alleviated neuronal hyperexcitability in cortical excitatory neurons of 5xFAD mice, evidenced by reduced action potential half-width, increased threshold potential, and decreased amplitude

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Notably, we found age-dependent brain atrophy in GCLC floxed X CaMKII-Cre mice (GCLC-KO) mice but not in wild-type (WT) mice (Fig