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These dosing conventions emerged from practitioner experience and extrapolation from preclinical models

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Additional studies describe exploratory evaluation of lipid-associated biochemical signaling models and peptide-related molecular interactions examined under controlled experimental conditions

Drucker DJ, Holst JJ

Since average CSMN axon length and the extent of neuronal branching and arborization enabled quantitative assessment of differences between healthy and diseased CSMN, these outcome measures were utilized to assess CSMN response to treatment with a cellular precision that was not possible before (Fig

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