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At high cell density, quinolones are secreted and detected by PqsR, which triggers the transcription of the phz operons, where the chorismic acid is modified into a tricyclic compound, and eventually, pyocyanin ( Figure 1 ) ( P

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For example, in the lungs, a high concentration of GSH is secreted by epithelial cells into a thin layer of fluid surrounding areas of gas exchange, and in the liver significant amounts are released into the plasma and bile

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