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Variety prevents hydration fatigue, especially when plain water triggers nausea

In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

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Both drugs reduced albuminuria by 24% over two years, with the most substantial reduction observed with semaglutide 1.0 mg (33%)