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Although this increases cytosolic gluconeogenesis, it is coupled with a crucial secondary effect: calcium transfer to mitochondria activates key tricarboxylic acid (TCA) cycle dehydrogenases, boosting mitochondrial energy expenditure and reducing ectopic lipid accumulation [50]

However, its use has been associated with various health risks, fueling the current wave of litigation

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Cardiac symptoms are frequently exertional, worsening with physical activity and improving with rest, though unstable angina or acute coronary syndrome can occur at rest

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A lower score suggests a gene is more likely to be essential in a cell line