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HNF-4 is a member of the nuclear receptor family of transcription factors, specifically identified as NR2A1

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Even at a relatively low dose (0.5 mg), they reduced their daily drinking by 41% and reported significantly lower cravings

In the same trial after 15-year follow-up, the mean annual occurrence of diabetes was 27% lower in patients assigned to lifestyle intervention and 18% lower in those randomized to metformin compared to placebo

Dunjic-KosticBIvkovicMRadonjicNVPetronijevicNDPantovicMDamjanovicAet al