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Moreover, the clinical translation of pharmacological agents targeting mitochondrial function and energy metabolism remains limited, highlighting the need for further investigation in both preclinical and clinical settings

In the context of Alzheimer's disease, the excessive and uncontrolled generation of superoxide by microglial NADPH oxidase contributes to significant oxidative damage, directly contributing to neurodegeneration and cognitive impairment ( 6.4 Inflammatory cytokines and mitochondrial damage Dysregulated microglial function plays a key role in various neurodegenerative, autoimmune, and viral diseases, such as Alzheimer's and Parkinson's disease

Nonetheless, the consideration of its potential gastrointestinal side effects and issues with tolerability is important in clinical decisions

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215, 425 Docherty, N

In a review of two studies comparing tirzepatide and semaglutide, people who were treated with the 15 mg dose of Zepbound experienced more nausea and other GI side effects than those treated with a 1 mg dose of Ozempic