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Ali agrees: Loss of muscle and bone loss can make someone more prone to falls. Falls are a major health concern for adults 65 and older, causing about 1 million hospitalizations per year, according to the Centers for Disease Control and Prevention

Starting body weight plays a significant role: patients beginning at higher weights often lose more total pounds, though the percentage of body weight lost remains similar across groups

PMID: 22396587, PMCID: PMC3509783, DOI: 10.1161/circoutcomes.111.962365

The appendix goes into detail about how they imputed values and tested different assumptions

This leads to many of the effects that we typically associate with aging, such as decreased muscle mass

Schriefer D, et al