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A correlation has been found between BA metabolism and glomerulosclerosis and tubulointerstitial fibrosis in DKD (127, 128), possibly through the inhibition of ligand-activated nuclear receptor Farnesoid X Receptor(FXR)/retinoid X receptor activation, which is strongly associated with ferroptosis (129)

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin