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According to FDA labeling, tirzepatide does not require dose adjustment for any degree of renal impairment, including end-stage renal disease

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The process highlights the deep historical stratification and the interplay between human practices and physical environment that contributed to shape the unique territorial identity

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It was clinically approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) in 2014 for the treatment of relapsing-remitting multiple sclerosis (MS), showing a significant efficacy over 2 years versus placebo and a favorable benefit-risk profile in two phase-III clinical trials, although with several adverse effects such as nausea, diarrhea, abdominal pain and leukopenia in some patients [282, 283]

It is one piece of a much larger risk management picture