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Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels

GLP-1 receptor agonists function by: Stimulating insulin release when blood sugar levels are high Reducing glucagon secretion, which helps lower blood sugar Slowing gastric emptying, leading to increased satiety Affecting appetite centers in the brain, reducing food intake While these mechanisms contribute to the drugs effectiveness, they may also play a role in potential side effects, including the rare but serious risk of NAION

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While Wegovy is generally well-tolerated, some patients may experience gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation

The degree of absorption of semaglutide depends on the amount of SNAC bound to it

FIGURE 1 2.2 Search strategy A systematic search of scientific literature was conducted in the Web of Science (Core Collection), Scopus, and PubMed databases, including studies published up to November 2025 without country restrictions