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FDA-APPROVED INDICATIONS Type 2 diabetes As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus Limitations of use: has not been studied in patients with a history of pancreatitis TYPE 2 DIABETES RCT SURPASS-2 trial - Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes, NEJM (2021) [PubMed abstract] The SURPASS-2 trial enrolled 1879 adults with type 2 diabetes who were inadequately controlled with metformin at a dose of at least 1500 mg per day Main inclusion criteria Age 18 years T2DM uncontrolled with metformin at 1500 mg/day A1C of 7 - 10.5% BMI 25 and stable for 3 months Main exclusion criteria Type 1 diabetes GFR 50 ng/L

We on the front lines are seeing the very real risks of obesity right now, and we should not deprive patients of medications that can reduce or even remove those risks entirely, she says

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75% of the women with PCOS suffer from insulin resistance, which makes weight loss even more difficult

Presentaciones de aGLP-1 de administracin diaria Se debe instruir al paciente sobre las nuevas posologas y condiciones de administracin de estos aGLP-1 (ver tablas anteriores) La semaglutida oral tiene unas condiciones de administracin exigentes que debe conocer el paciente

Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects