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If you have a B12 deficiency, the risk of stopping treatment is far greater than the risk of having elevated B12 levels

However, this is considered an underestimation as it will be unlikely to be detected in smaller clinical trials, and a more recent study in 2010 found that NSAIDs including ibuprofen (odds ratio of 2.24, 95% confidence interval (CI) = 1.992.52) increased the risk of hospitalization due to acute hepatitis (odds ratio 2.13, 95% CI = 22.18) 35

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