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Below is a list of the advantages and disadvantages associated with GLP-1 receptor agonists, as noted by the FDA and NLM
doi: 10.1016/j.cgh.2018.05.020 9
The molecular structure of GLP-1 peptides is large, hydrophilic, and electrically charged, which severely limits the ability of the molecule to pass the outer layer of the skin and enter the bloodstream, says Edwin Davila, DO, resident physician and obesity medicine expert for the National Academy of Sports Medicine
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Safety Concerns The proliferation of compounded GLP-1s was accompanied by safety concerns, largely because compounded drugs were not reviewed by the FDA prior to distribution
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