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Lupus 27 , 243256 (2018)

Metformin has been found to produce antidepressive effects by enhancing the responsiveness of the serotoninergic neurons in the dorsal raphe [47], but the main impact of GLP-1 is exerted by AMP-activated protein kinase (AMPK), a major cellular regulator of lipid and glucose metabolism [48]

Source Data Extended Data Fig./Table 1 (download XLSX Statistical source data