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Overall, the effects of these compounds on fat metabolism, body mass index, lean mass, and insulin sensitivity might show changes in body weight on long-term treatment, yet they are less likely to offer the same results as GLP-1 patches

GLP-1 receptors are found in the brain and the pancreas

The study design included sequential rounds of a three-day vehicle-treated baseline phase, a three-day treatment phase, and a two-to-three-day washout phase

Many patients lose meaningful weight

The skin effects may also run in two directions at once

No contraindications (e.g., personal/family history of medullary thyroid carcinoma or MEN2, pregnancy)