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The downside is that it costs more, and there are potential side effects

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At steady state, single deviations such as a missed or double dose, a dose with shorter (15 min) or longer (120 min) post-dose fasting time or a dose taken with a larger volume of water (240 mL) will result in only minor and transient changes in exposure

b Estimated using an ANCOVA based on data irrespectively of discontinuation of trial product or initiation of rescue medication adjusted for baseline value, background medication, renal status and region