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Western blot analysis for protein expression of GLP-1R in the renal pelvis The kidneys of rats were removed, frozen on dry ice and then stored at 80 C

The initial results of GLP-1RAs effects on bone metabolism and anti-osteoporosis sound promising and meaningful, but they should be interpreted with caution and in the context of the trials

GLP-1 medications, such as Semaglutide and Tirzepatide, mimic a hormone released in the gut, enhancing feelings of fullness, suppressing appetite, and slowing gastric emptying, which helps reduce caloric intake and promotes weight loss

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In clinical trials for Ozempic (SUSTAIN programme), patients experienced weight reductions of approximately 3.5-6.5kg over 30-56 weeks, depending on the dose