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Furthermore, because ALCAR can influence thyroid hormone activity by blocking the entry of thyroid hormone into the cell nucleus, individuals with hypothyroidism or those taking thyroid replacement medications should use ALCAR with caution and under medical supervision

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These substances include contaminants, artificial chemicals, heavy metals, and processed foods

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A small case-controlled study comparing 52 DS cases to 52 control cases noted that average maternal serum homocysteine concentration was slightly higher in mothers giving birth to children with DS but this difference was not statistically significant (Mohanty et al 2012)