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More severe issues of GLP-1s can include: Pancreatitis, or severe abdominal pain radiating to the back, and vomiting Bowel obstruction, which consists of severe abdominal pain, vomiting, bloating, and constipation Severe gastroparesis, a chronic condition characterized by delayed stomach emptying without a physical blockage Identifying the Signs of Pancreatitis and Obstruction These can seem similar to many of the common side effects, so its important to know the difference