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A major challenge for any preventative therapy is that much of the mitochondrial dysfunction in the brain of PD patients may have already occurred before the point of diagnosis during the prodromal period, see the excellent review by Schapira and Tolosa (2010)

Lavallard VJ, Meijer AJ, Codogno P, Gual P

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Patients were asking if it was safe to use their GLP-1 therapy with nodular disease and a history of thyroid cancer or concern for thyroid cancer

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