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No, there is no established clinical evidence that B12 injections cause weight loss in individuals with normal B12 levels

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The Annals of Pharmacotherapy , 46 (2), 240247

This is why we view it as one component of a larger, personalized health strategy designed for lasting performance, not just a temporary fix

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If a patient has specific or red flag features B 12 deficiency testing should be initiated (see Figure 1: B 12 Test Result Review and Process Algorithm for Patients with Risk Factor for B 12 Deficiency * and/or Non-specific ** or Specific Symptom of B 12 Deficiency )