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AGEs promote the accumulation and cross-linking of extracellular matrix (ECM) proteins, contributing to vascular sclerosis and fibrosis, which further progress to diabetic cardiomyopathy and diabetic nephropathy [32,33,34,35]

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It implies that ER is required for execution of this RCD [164]

Clin Rev Allergy Immunol 66(2):164191 Singh TP, Schn MP, Wallbrecht K, Gruber-Wackernagel A, Wang X-J, Wolf P (2013) Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis

When you eat carbohydrates, your blood sugar rises