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Available at Accessed 01/10/2023

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AR-directed manipulation of host immune cells may offer a promising therapeutic approach for many types of cancers

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Past drugs had both modest efficacy (e.g., only 5% body weight loss) and/or serious side effects (e.g., fen-phen was used widely for weight loss in the 90s, but after the discovery that one of the components caused heart valve problems, it was recalled from the market2)

Importantly, there were no statistically significant differences in local, locoregional, or distant recurrence rates between treated and untreated patients, offering preliminary reassurance about oncologic safety