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The Control group and Model group were given distilled water by gavage, while the Low group and High group were given 150 mg/kg and 300 mg/kg berberine by gavage respectively

GLP-1 receptor agonists like semaglutide and tirzepatide mimic a gut hormone that regulates appetite, slows gastric emptying, and improves insulin sensitivity

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Sapey-Triomphe LA, Lamberton F, Sonie S, Mattout J, Schmitz C

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Notably, the participants did not lose much weight during the trial, suggesting that the decrease in headaches was not associated with weight loss