can semaglutide not work Why You're Losing Weight on GLP-1 Medications: A Dietitian's Perspective Why Semaglutide Stops Working &

Skipped periods A 2023 research review mentioned that losing 10%--15% of your body weight in a short period of time can cause amenorrhea , the medical term for missed periods

Weight loss plateaus occur for several reasons: Metabolic Adaptation: The body lowers its energy expenditure to preserve fat stores

On restarting, the weight loss curve typically follows a compressed version of the original timeline, reaching previous weight within 60 to 75 percent of the original timeframe

Last reviewed: June 20, 2026 Last updated: June 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Youre still building up to therapeutic levels