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In a 13-week study on mice (0, 7.5, 15, 50, 275 or 750 mg/kg in the diet), increased incidences of hyperplasia and hyperkeratosis of the squamous epithelial cells of the forestomach occurred in males and females at 50 mg/kg diet and above

When the Krebs cycle spins efficiently, the cell produces abundant ATP, giving your muscles the energy to move and your brain the energy to think clearly

10.1038/35067582 Nat

That's not a guarantee of better results - it's a different strategy worth discussing with a clinician

Doctors call this a loss of lean mass

Along with prior studies showing that SGLT2i robustly reduce the risk of hospitalization for HF among patients with T2DM with or without established CVD or HF (91), these results suggest adaptations of consensus proposals to prioritize use of SGLT2i in T2DM patients at risk for or with established HF (Figure 3, Central Illustration)