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Anal fissure anatomy Once a fissure develops, the internal anal sphincter typically goes into spasm, causing further separation of the tear, constricting blood flow to the area, impairing healing, and causing pain

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Allow the reconstituted vial to reach room temperature for 10 to 15 minutes before drawing each weekly dose for improved injection comfort

This formulation assists in shielding cells from oxidative stress and mitigating damage caused by unstable free radicals

10.1152/ajprenal.00077.2012 217 YasmeenZ.BasitA.TahirS