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Further molecular mechanical analysis revealed that CM markedly enhanced VLDLR expression and decreased SREBP-1c and ApoB expression at the protein level in the liver, and significantly increased the protein expression of LXR/ABCG5 in the small intestine, as well as downregulation of the protein expression of PPAR and ATGL in the epididymal fat ( Pleurotus ostreatus polysaccharides fraction reduced liver triglyceride level through modulating the expressions of Dgat1, Ldlr, Nr1h4, Acat1, Srebf1, and Srebf2 in diet-induced hypercholesterolemic mice ( Trametes versicolor polysaccharide (EVP) dramatically reduced serum TC, TG, LDL-C, and atherosclerosis index in a dose-dependent manner in high-fat diet-induced hyperlipidemic mice

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In combination-therapy (Metformin + Berberine) the adverse events disappeared in one week after reduction in berberine dosage

investigation 131 (5), e140853

14 Concentrated isoflavone supplements are a separate question with less evidence, so whole foods are the safer starting point

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