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Recent studies have shown that the lncRNA 00312/miR-34a-5p/ASS1 axis reduces proliferation and invasion and promotes apoptosis in RCC (113), and that the SNHG12/SP1/CDCA3 ferroptosis-related long non-coding RNA (FRIncRNA) axis promotes RCC progression and sunitinib resistance, thereby serving as a new target for the treatment of sunitinib-resistant RCC (114)

Tartagni et al., 2015

Deviations in this important signalling disbalances the homeostasis that protects from tumorigenesis, infection and excessive forms of inflammation ( The study of A