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While analogs with reduced IGFBP affinity show increased potency in vitro, careful pharmacokinetic work has shown that such analogs are actually cleared more rapidly than native IGF-1 after parenteral administration in vivo, because the binding proteins that inhibit activity also serve as a circulating reservoir that prolongs systemic presence

Serum Uric Acid and Risk of Chronic Heart Failure: A Systematic Review and Meta-Analysis

Therefore, the rational use of these mechanisms in the biomedical field to regulate cell ferroptosis and specifically induce tumor cell ferroptosis during tumor treatment is a promising cancer treatment strategy [215]

Dreischer P, Duszenko M, Stein J, Wieder T

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