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Vitamin C and copper peptides should generally not be applied in the same routine: the low pH of L-ascorbic acid can destabilise GHK-Cu, and the combination has been linked to increased irritation in some users

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However, antidepressants are still sometimes prescribed to help if patients are experiencing depression ( Treating comorbidities ME/CFS displays an overlap with several autoimmune or immune-mediated diseases that also have chronic fatigue as a main symptom, such as Hashimotos thyroiditis (530), fibromyalgia (FM) (532, 554557), Mast Cell Activation Disorder (532), sleep apnoea (532), IBS (532), secondary depression or anxiety (532), Ehlers-Danlos syndrome (532), and PoTS (532, 558563)

Thus, scavenging ROS is expected to reduce the levels of these cytokines