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It creates a chronic pro-oxidant environment that overwhelms the already-depleted GSH-based antioxidant network in diabetic patients
In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results study, a numerically higher incidence of complications associated with DR, such as panretinal photocoagulation, anti-VEGF injection, vitreous hemorrhage, and blindness, was observed, although results did not reach clinical significance
Behav Cognit Neurosci Rev
An unexpected finding in our studies was the loss of improved lipid tolerance in Dpp4 EC/ mice, with or without coadministration of sitagliptin, following BMT, implying an interaction between bone marrowderived cells and the metabolic actions emanating from the reduction of DPP-4 activity in endothelial cells
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