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Morning injection (6 to 8 AM) puts the nausea window during your active day, which some people prefer because movement and distraction reduce perceived nausea
Supply chain issues have also impacted GLP-1 adherence
The only clinically relevant difference between treatments was the higher frequency of gastrointestinal related adverse events with IcoSema versus icodec or semaglutide alone, which can be mitigated by appropriate dosing recommendations for IcoSema, as discussed above
This effect is central to their ability to reduce appetite and promote feelings of fullness, but it also means that food and stomach contents remain in the stomach for longer than usual, which can trigger nausea, bloating, and discomfort