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Injectable versus oral tirzepatide The standard and most established form of tirzepatide is the subcutaneous injection

Following a structured dosage plan also makes it easier to monitor your reactions to the medication and to make adjustments to your dose as needed

Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management and chronic weight management

Typical treatment duration Most tirzepatide treatment courses run 12 to 18 months for initial weight loss, followed by an indefinite maintenance period

39 In the SURMOUNT-1 and SURMOUNT-3 trials, the weight loss ranged between 15% and nearly 21% after 72 weeks of treatment

Bottom line in plain language: Both medications work extremely well but tirzepatide generally leads to 510% more total body weight loss than semaglutide