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GLP-1GIP Tirzepatide GLP-1 GIP GLP-1 OzempicSaxenda Tirzepatide GIP 4 1 2 3 4 6 1

Earlier studies had already suggested that Ozempic and Wegovy users faced roughly double the risk of NAION compared to patients using other treatments

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These effects are generally mild to moderate and tend to improve within 24 weeks as the body adjusts to the medication

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Based on this, our results suggest that the sequence of modulatory effects on glucose metabolic homeostasis exhibited by the binding of GLP-1 to its receptor are possibly influenced, to a greater extent, by the interaction of GLP-1 with its pancreatic receptor and are less dependent on interaction with hepatic GLP-1R