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doi:10.1155/2015/806979 Epub 2015 May 17

They also helped those patients lose weight

Food related neural activity and development of satiety were effectively restored by leptin replacement in lipodystrophy (227)

Beyond obvious effects on energy balance, dietary quality can also influence obesity risk through changes in metabolic adaptation due to a high refined carbohydrate diet, in resting energy expenditure (such as through brown or beige adipose tissue thermogenesis), in microbiome calorie utilization (with corresponding greater or lesser utilization by the host tissues), and in epigenetic or trans -generational risk of obesity [81,82]

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