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Orlistat, a lipase inhibitor that reduces fat absorption, is licensed for weight management in the UK and may be prescribed for adults with a BMI 30 kg/m (or 28 kg/m with comorbidities), with appropriate monitoring for nutritional adequacy and side effects

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Sudden weight loss can rapidly reduce facial fat, leading to changes such as skin shrinkage, sagging, and decreased elasticity

Participants will administer the injection once a week and will follow a dose escalation schedule over a period of 16 weeks until they reach 2.4 mg weekly

However, alcohol disrupts sleep architecture (particularly REM sleep), impairs melatonin production, and increases cortisol, essentially working against everything pineal peptides are trying to achieve