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Retatrutide is not yet licensed by the MHRA or EMA and is only available through regulated clinical trials in the UK

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Compared to endogenous GLP-1 and glucagon, retatrutide demonstrates lower potency at GLP-1 and glucagon receptors but substantially higher potency at the human GIP receptor a pharmacological profile deliberately engineered to balance efficacy with tolerability

Hseu YC, Vudhya Gowrisankar Y, Chen XZ, Yang YC, Yang HL