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Sci Transl Med 2020;12:eaay8071.ArticlePubMedPMC 105
The dosing regimen consisted of 5 mg/kg [34] given 12 h before ischemia induction, followed by twice-daily maintenance doses (every 12 h) until tissue collection, ensuring plasma concentrations above 200 ng/mL based on published pharmacokinetics (T/ = 10.5 h in rats).Control groups received equivalent volumes of vehicle (0.1% DMSO for intrathecal, corn oil for oral)
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